Announcements
REU Students Present
Research Findings At CCSB
Symposium
Accepting Applications for Pilot Grants for Faculty Career Development!
Junior and senior faculty interested in broadening their investigative research in the area of Systems Biology are invited to apply for pilot grants of up to $50,000 per year for two-year terms.
Accepting Applications for the CBC Research Fellow Program
Doctoral scientists interested in fellowships to study the principles of transcriptional regulatory networks are invited to apply.
Latest News
Chicago Cancer Genome Project studies genetics of 1,000 tumors
Over the past year, working closely with physicians, the IGSB team at the University of Chicago collected complete sequence data for genes expressed by 100 tumors―primarily breast cancer, head and neck cancer, and leukemia. Correlating genetic data with patient outcomes, they have begun to identify genetic patterns within tumors that may help them predict how a cancer will behave. Many experts believe such information will increasingly guide treatment.
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A new study led by CCSB Director Kevin White could lead researchers to a new set of drug targets for treating breast cancer
The most common forms of breast cancer are fueled by the female hormone estrogen. By comparing the effects of estrogen and retinoic acid on the entire genome, the researchers found that they have a "yin-yang" effect. They alter the expression of many of the same genes, with estrogen tipping the scales towards cell proliferation and retinoic acid restoring the balance by inhibiting cellular growth.
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CCSB investigator Richard Carthew demonstrates that a microRNA called miR-7 is critical to the robustness of the molecular network that helps regulate uniformity
In a study of Drosophila, when the researchers eliminated miR-7, the networks remained intact but only under uniform environmental conditions. When the researchers perturbed the environment by modulating the temperature, the networks failed to keep things intact, and animals suffered from developmental defects. If the microRNA was present, however, the networks resisted the temperature fluctuation, and animals were normal and healthy. Read more »
CCSB investigator John Reinitz demonstrates that developing fruit fly embryos are capable of error corrections
Animals have an astonishing ability to develop reliably, in spite of variable conditions during embryogenesis. New research, published in parallel this week in PLoS Biology and PLoS Computational Biology, addresses how living things can develop into precise, adult forms when there is so much variation present during their development stages. A team led by John Reinitz at Stony Brook University, and funded by the National Institutes of Health, shows how fruit fly embryos can "forget" initial incorrect versions of their body plan and develop into recognizable adult flies. Read more »
Events
CCSB Retreat
The next CCSB retreat will be held February 25, 2011, from 8:30am  6:00pm at the University of Chicago.
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NIGMS